The main causes of stagnant agriculture include depletion and degradation of natural resources, increasing biotic and abiotic stresses, poor seed replacement rate, soil nutrients draining excessively, indiscriminate use of pesticides, changing soil microbial dynamism, lack of low input-highly profitable concept of technologies and overall lack of attempt for holistic approach to address problems. The present study discusses the novel approaches evaluated using low input-highly profitable technologies. Benefit: cost (B:C) ratio in various models of integrated farming system (IFS) ranged from 2.4-3.0 in comparison to 1.5-1.6 in traditional farming. Optimum utilization of family manpower in various IFS models was 67 to 187 man days/year during 3 years observation period. Resource generation options explored were goat, rural poultry (new technology), pig, high value vegetables (off season), cut flowers, cash crops, subsidiary units as apiculture and mushrooms. Two models of rural poultry production were developed aiming the landless and marginal farmers for resource generation and to diversify the livelihood base and self-employment. Integration of all the 3 models (third model of local chick production) enhanced production and profitability many times and B:C above 7.0. The novel low cost preventive and therapeutic formulation against mastitis and anestrous/infertility were also developed. A bio-enhancer (CSR-BIO) comprising consortium of microbes enhanced nutrient uptake and increased yield by 20-39% in sodic as well as normal soil. This created sustainable livelihood security and will also assure environmental security. Improved concept and models named as specialized IFS (SIFS) was developed with holistic approach and gave encourage results.