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Alteration of fibronectine expression in the
kidney extracellular matrix following nicotine
administration in gestation and lactation period
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Hasan Pahang1*,
Mohammad Reza Nikravesh2 and Mehdi Jalali2 |
1Department of Anatomy, faculty of medicine, North
Khorasan University of Medical Sciences, Bojnord, Iran
2Department of Anatomy and Cell Biology, Faculty of
Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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Abstract |
The aim of this study was
to assess the effects of maternal nicotine exposure during pregnancy and
lactation periods on fibronectine expression in the extracellular matrix
of kidney of offspring. A
total of 24 female pregnant Balb/c mice
were randomly divided into four groups as follows: 3 mg/kg/day nicotine
intraperitonealy (IP) from the 6th day of uterine life until
the end of pregnancy (E1), 3 mg/kg/day nicotine in a similar way from
the first day of delivery to the end of lactation (E2), 3 ml/kg/day
normal saline during pregnancy and lactation period as suggested for E1
and E2. The results showed that fibronectine reaction was
significantly increased in the glomerule of E1. RT-PCR results
demonstrated that the mRNA level of the fibronectin in the E2 group was
up regulated significantly compared to the other group. From the results
of the present study showed that maternal
nicotine administration did not alter fibronectine expression in
gestation and lactation life.
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Keywords:
Maternal nicotine;
fibronectine; kidney; extracellular matrix
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To cite this article:
Pahang H, Nikravesh MR and
Jalali M, 2016.
Alteration of fibronectine expression in the
kidney extracellular matrix following nicotine administration
in gestation and lactation period.
Res.
Opin.
Anim. Vet. Sci., 6(5): 138-143. |
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