|
PRINT: ISSN 2221-1896
ONLINE : ISSN 2223-0343
|
|
|
Hypoglycemic effect of Aloe vera on streptozotocin-induced
diabetic mice
|
|
Sina Mojaverrostami1*, Ali Asghar Tehrani2, Bita
Lotfallahzadeh1 and Mahsa Khamisabadi1
|
1Department
of
Veterinary Medicine; 2Department of Pathobiology, Faculty of
Veterinary Medicine, Urmia University, Urmia, Iran
|
|
Abstract |
In the present study, an attempt was made to evaluate the effects of
hydro-alcoholic extract of Aloe vera in streptozotocin-induced
diabetic mice. A total 48 white lab mice were divided into four groups
(n=12). One group served as control which was neither diabetic nor
treated with Aloe vera. Second group was normal and treated with
Aloe vera orally at the dose rate of 300 mg/kg. Third
group was diabetic and in fourth group was also diabetic but treated
with Aloe vera. The glucose analogue, streptozotocin was used to
induce diabetes. After a week treatment of Aloe vera, the glucose
level returned to normal.
Histologically, the islet of Langerhens in pancreas was damaged in
diabetic mice which were restored by feeding
Aloe vera. The hepatocytes of
diabetic rats were swollen. These degenerative changes were repaired by
supplementation of Aloe vera.
Similarly, in the kidney and small intestines, the degenerative changes
were restored by the addition of
Aloe vera in the feed. The present study demonstrated that
Aloe
vera have a beneficial effects in treatment of diabetes.
|
Keywords:
Aloe vera;
diabetes; streptozotocin; pancreas |
|
To cite this article:
Mojaverrostami S, AA Tehrani, B Lotfallahzadeh and M Khamisabadi,
2014.
Hypoglycemic effect of Aloe vera
and histology of organs on
streptozotocin-induced Diabetic Mice.
Res.
Opin. Anim. Vet. Sci., 4(4), 186-191. |
|
|