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The study of caseous lymphadenitis: dose dependent infection of C. pseudotuberculosis in mouse model via oral inoculation

Abdinasir Yusuf Osman1,2, Faez Firdaus Jesse Abdullah1,3*, Lawan Adamu1,5, Tuba Thabitah Abdullah1, Mohd Hero Azuan1, Abdul Rahman Omar2,4, Abdul Wahid Haron1 and Abdul Aziz Saharee1

1Department of Veterinary Clinical Studies; 2Department of Veterinary Pathology and Microbiology;3Research Centre for Ruminant Disease, Faculty of Veterinary Medicine, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; 4Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia;5Faculty of Veterinary Medicine, University of Maiduguri, PMB1069, Borno State, Nigeria

 
Abstract

The use of different dependent doses design offers unique opportunities to advance the study of diseases through the investigation of their respective outcomes at multi-disciplinary level. Such design can increase our understanding of the factors that shape disease establishment, course development and distribution of lesions in space and time. This paper utilizes three different doses of C. pseudotuberculosis, 103, 105 and 107 colony forming unit (CFU/ml) and illustrates their potential of disease induction at a range of histo-pathological and molecular scales. A mouse model is used to demonstrate the potential aspects of the doses in relation to the outcome of interest. Our approach is based on comparing the observed patterns of clinical features, postmortem and gross finding, as well as histo-pathological and molecular levels.

Keywords: Caseous lymphadenitis; dose dependent infections; mouse; oral inoculation; pathological features and PCR
 
To cite this article: Osman AY, FFJ Abdullah, L Adamu, TT Abdullah, MH Azuan, AR Omar, AW Haron and AA Saharee, 2014. The study of caseous lymphadenitis: dose dependent infection of C. pseudotuberculosis in mouse model via oral inoculation. Res. Opin. Anim. Vet. Sci., 4(3), 163-169.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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