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PRINT: ISSN 2221-1896
ONLINE : ISSN 2223-0343
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The study of caseous lymphadenitis: dose dependent
infection of C. pseudotuberculosis
in mouse model via oral inoculation
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Abdinasir Yusuf Osman1,2, Faez
Firdaus Jesse Abdullah1,3*, Lawan Adamu1,5, Tuba
Thabitah Abdullah1, Mohd Hero Azuan1, Abdul Rahman
Omar2,4, Abdul Wahid Haron1 and Abdul Aziz Saharee1
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1Department of Veterinary Clinical Studies; 2Department
of Veterinary Pathology and Microbiology;3Research Centre for
Ruminant Disease, Faculty of Veterinary Medicine, University Putra
Malaysia, 43400 UPM Serdang, Selangor, Malaysia; 4Institute
of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia;5Faculty
of Veterinary Medicine, University of Maiduguri, PMB1069, Borno State,
Nigeria
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Abstract |
The use of different
dependent doses design offers unique opportunities to advance the study
of diseases through the investigation of their respective outcomes at
multi-disciplinary level. Such design can increase our understanding of
the factors that shape disease establishment, course development and
distribution of lesions in space and time. This paper utilizes three
different doses of C.
pseudotuberculosis, 103, 105 and 107
colony forming unit (CFU/ml) and illustrates their potential of disease
induction at a range of histo-pathological and molecular scales. A mouse
model is used to demonstrate the potential aspects of the doses in
relation to the outcome of interest. Our approach is based on comparing
the observed patterns of clinical features, postmortem and gross
finding, as well as histo-pathological and molecular levels.
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Keywords:
Caseous lymphadenitis; dose dependent infections; mouse; oral
inoculation; pathological features and PCR |
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To cite this article:
Osman AY, FFJ
Abdullah, L Adamu, TT Abdullah, MH Azuan, AR Omar, AW Haron
and AA Saharee, 2014.
The
study of caseous lymphadenitis: dose dependent infection of
C. pseudotuberculosis in mouse
model via oral inoculation.
Res.
Opin. Anim. Vet. Sci., 4(3), 163-169. |
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