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PRINT: ISSN 2221-1896
ONLINE : ISSN 2223-0343
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Lymphocytic proliferation and interleukin-2 production in chickens
supplemented with growth promoters |
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Shawky Mahmoud1, Mostafa Shukry1,2* and Michel
Saad1
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1Department
of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University,
Egypt
2Department
of Biomolecular Science, Faculty of Drug Discovery, Gifu University, Japan
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Abstract |
The efficacy and safety of growth promoters as immunopotentiators in
chickens have been extensively evaluated under laboratory conditions. In
this study, 210 (day old chicks) chicks were allotted into seven groups.
Group 1 served as a control, group 2 and 3 were fed Reomin. Group 4 and
5 were supplemented with Gibberellic acid, a plant hormone with
androgenic features, through drinking water (single and double doses).
Group 6 and 7 were fed Digestamin supplemented to basal diet at
recommended single and double doses. All chicks were vaccinated against
H5N1twice at three weeks interval. Blood samples as well as tissue
specimens were collected for assessment of T-Lymphocyte Proliferation
Assay (LPA), differential leucocyte count, serum total protein and
albumin and interleukin-2 (IL-2) production. Furthermore, wattle dermal
reaction was conducted. The Gibberellic acid treated groups showed
highest lymphocytic count and IL-2 production. Meanwhile chickens
treated with probiotics showed highest values of LPA, total serum
proteins and globulin as well as wattle dermal thickness. These results
indicated that the evaluated growth promoters are safe and efficacious
for enhancing immune response against H5N1antigen.
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Keywords:
Lymphocyte; interleukin-2; chickens; growth promoters |
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To cite this article:
Mahmoud S, M Shukry and M Saad,
2013.
Lymphocytic proliferation and interleukin-2 production in chickens
supplemented with growth promoters.
Res.
Opin. Anim. Vet. Sci., 3(3), 68-72. |
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