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Protective effect of
Moringa peregrina
seed
oil
against doxorubicin-induced hepatotoxicity in male mice
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Abdallah M. Sliai1* and Gamal H. Abdel-Rahman2 |
1،2Department of Biology, Faculty of Science, Taif
University, Taif, KSA
1Department of Zoology, Faculty of Science, Assiut
University, Assiut, Egypt
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Abstract |
The present study aimed
to illustrate the histopathological and immunohistochemical changes in
the liver of mice exposed to anticancer drug, doxorubicin (DOX), and to
evaluate the possible protective role of Moringa peregrina seed
oil. Thirty two mature male mice were randomly divided into four groups.
One group served as a control, the other was given a dose of M.
peregrine at the rate of 150 mg/kg body weight, third group was DOX
treated, and fourth was DOX plus M. peregrina treated.
Histo-pathological examination of liver sections showed that DOX
caused
disturbance in hepatic cords, hepatocytes degeneration, inflammation,
necrotic areas, vacuolation and dilation of the blood sinusoids.
Doxorubicin treated animals demonstrated a positive reaction to
Caspase-3 in hepatocytes as compared with controls. Administration of
M. peregrina seed oil plus doxorubicin showed reduction in caspase-3
immunoreactivity and apoptotic index induced by DOX. Treatment with
M. peregrina seed oil 150 mg/kg body weight reduced the damage
caused by DOX in the liver.
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Keywords:
Doxorubicin; Moringa
seed oil; histopathology; liver; mice
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To cite this article:
Sliai AM and GH Abdel-Rahman, 2016.
Protective effect of
Moringa peregrina
seed oil against
doxorubicin-induced hepatotoxicity in male mice.
Res.
Opin.
Anim. Vet. Sci., 6(2): 69-73. |
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