Parathion is an insecticide has been demonstrated to be a highly toxic compound for animals and humans. It has been used widely in agriculture and domestic. Many cases of acute poisoning have been reported over the past few decades when exposed to parathion.  The present work was designed to evaluate the protective role of lycopene against renal histopathological and biochemical changes due to exposed to insecticide parathion. The animals were divided into four groups with six in each:  Group I: served as control animals received saline, Group II:  receive lycopene (10 mg/kg b.w) orally. Group III:  received once daily methyle parathion at a dose of 0.28 mg/kg b.w. (1/50 LD₅₀ oral dose). Group IV:  receive once daily methyle parathion at a dose of 0.28 mg/kg b.w. plus lycopene (10 mg/kg b.w.). Histological examinations revealed that parathion caused glomerular atrophy, dilated renal tubules, haemorrhage, oedema and necrosis. Immunohistochemical localization of Bax for apoptosis was performed. Methyle parathion treated animals showed positive reaction to Bax in glomerulii and renal tubules as compared with controls. Methyle parathion treated animals showed also and increased in lipid peroxidation and decreased antioxidant enzyme, glutathione. Coa-dmnistration with lycopene decrease pathological changes, apoptosis, lipid peroxidation and increase antioxidant enzyme.