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PRINT: ISSN 2221-1896
ONLINE : ISSN 2223-0343
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Protection by wheat germ oil against doxorubicin-induced pathological
changes and apoptosis in the kidney of male mice
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Abdallah M. Sliai1 and Gamal H. Abdel-Rahman2* |
1،2Department of Biology, Faculty of Science, Taif
University, Taif, KSA; 1Department of Zoology, Faculty of
Science, Assiut University, Assiut, Egypt
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Abstract |
Doxorubicin is a highly
effective antineoplastic agent, but it is well known for its oxidative
damage to various body organs such as nephrotoxicity. The present study
aimed to investigate the possible protective role of the natural
antioxidant wheat germ oil on Doxorubicin -induced kidney toxicity.
Studies were performed on four groups of mice. Control group, wheat germ
oil group (100 mg/kg b.w.), Doxorubicin group (2.5 mg/kg/day) for seven
days, and doxorubicin plus wheat germ oil group. Histopathological
examination of kidney sections revealed that doxorubicin caused
glomerular congestion with wide Bowman’s space and widened tubular
lumen. Immunohistochemical localization of Caspase-3 for apoptosis was
performed. Doxorubicin treated animals showed positive reaction to
Caspase 3 in glomerulii and renal tubules as compared with controls.
Administration of wheat germ oil reversed kidney damage with a
marked reduction in tubular damage and apoptosis induced by doxorubicin.
These results have suggested that wheat germ oil ameliorated doxorubicin
-induced nephrotoxicity in male mice.
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Keywords:
Doxorubicin, wheat germ
oil, histopathology, kidney, mice |
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To cite this article:
Sliai AM and GH Abdel-Rahman, 2014.
Protection by wheat germ
oil against doxorubicin-induced pathological changes and apoptosis in
the kidney of male mice.
Res.
Opin. Anim. Vet. Sci., 4(12): 695-700. |
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