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Evaluation of effectiveness of pest des petits ruminants vaccine in
Northern Tanzania
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1Daniel
Mdetele*, 2Subira Mwakabumbe, 3,4Misago Seth and
2,5Michael Madege |
1Sokoine
University of Agriculture, Faculty of Veterinary Medicine, P. O. Box
3015, Chuo Kikuu Morogoro, Tanzania; 2Zonal Veterinary Centre
lake zone, P.O Box 127 Mwanza, Tanzania; 3The Nelson Mandela
African Institution of Science and Technology, School of Life Sciences
and Bioengineering, P. O Box 447, Arusha, Tanzania; 4National
Institute for Medical Research (NIMR), Tanga Medical Research Centre,
P.O Box 5004, Tanga, Tanzania; 5Zonal Veterinary Centre
Northern zone P.O Box 1068 Arusha Tanzania
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Abstract |
After the incursion of Peste des Petits ruminants (PPR) in Tanzania in
2008, Ministry of Livestock and Fisheries Development (MLDF) in
collaboration with development partners started to control the disease
by vaccination of sheep and goats through
the Vaccination for Control of Neglected Animal Diseases in Africa
(VACNADA) project. Vaccination
was carried out in Northern and Lake Zones, where Tanzania borders
Kenya, the known entry point for the disease in East Africa. A cross
sectional epidemiological study was carried out in the Tarime district
to evaluate the effectiveness of PPR control by vaccination implemented
in Tanzania. A total of 360 serum samples, 180 pre-vaccination and 180
post-vaccination of sheep and goats were randomly retrieved from lake
zone. Retrieved serum samples were serologically analyzed using a
monoclonal antibody-based competitive enzyme-linked immunosorbent assay
(c-ELISA) to assess the seroprevalence of PPR before and after
vaccination. There was a
statistically significant difference in seroconversion between pre- and
post-vaccination samples. The pre-vaccination and post-vaccination
seroprevalence of PPR in sheep and goats from nine representative
villages were found to be 3.3% and 71.3% respectively (P<0.0001).
Mean change in seroconversion rates across villages was found to be
67.8% (range 45 to 80%). Significantly higher acquisition of
antibodies following vaccination suggests positive response that could
be protective for sheep and goats against PPR. Efforts should be made to
upscale vaccination coverage as well as carrying out further studies to
evaluate the role of PPR vaccination in protection against this disease
in small ruminants.
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Keywords:
PPR vaccine; effectiveness; competitive ELISA; Tanzania |
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To cite this article:
Mdetele D, S Mwakabumbe, M Seth and M Madege,
2015.
Evaluation of effectiveness of pest des petits ruminants vaccine in
Northern Tanzania.
Res.
Opin. Anim. Vet. Sci., 5(10): 401-405. |
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